DOXYCYCLINE 50 TABLETS
Doxycycline 50 contains Doxycycline (as monohydrate) 50mg per tablet.
Doxycycline belongs to the tetracycline group of antimicrobials and these were developed in the late 1940’s. Tetracycline antibiotics inhibit protein synthesis by binding to the 30S subunit of the ribosome and thus interfering with RNA-protein translation. They gain access to the ribosome via passive diffusion through hydrophilic pores in the outer cell membrane and energy dependant active transport through the inner cytoplasmic membrane. This involves a periplasmic protein carrier. Tetracyclines have good broadspectrum bacteriostatic activity and Doxycycline has a broader spectrum of activity than many others of the group because it is more lipophilic and this leads to higher tissue penetration and a higher volume of distribution. The spectrum of activity of doxycycline includes; Bacillus sp, Corynebacterium sp, Erysipelothrix rhusiopathiae, Listeria monocytogenes, Streptococci, Actinobacillus sp, Bordetella sp, Brucella sp, Haemophilus sp, Pasteurella multocida, Yersinia sp, Campylobacter foetus, Borrelia sp, Leptospira sp, Actinomyces sp, Fusobacterium sp, Mycoplasma sp, Chlamydia sp, Rickettsia sp, some protozoa and Anaplasma sp. Variable activity has also been demonstrated against some Staphylococcus and Enterococcus sp and members of the Enterobacteriaceae family such as Escherichia coli, Enterobacter sp, Klebsiella sp, Proteus sp, Salmonella sp and some anaerobes such as Bacteriodes sp and Clostridium sp. Doxycycline is well absorbed from the gastrointestinal tract and distributed rapidly and extensively to almost all tissues and body fluids. High concentrations are found in the heart, kidneys, muscle, liver, bile, lungs, spleen and bones. Good levels of doxycycline are also attained in the pleural fluids, bronchial secretions, synovial fluid, cerebrospinal fluid, ascitic fluid, prostatic fluid, vitreous and aqueous humour, saliva and tears. Excretion of doxycycline is different from that of the tetracyclines. It enters the intestines via direct diffusion or excretion and is then excreted in the faeces. Doxycycline is excreted in an inactive form in the faeces and so there is little impact on the microflora of the lower intestine. In dogs renal excretion may account for 25% and biliary excretion less than 5%.
Treatment of infections caused by doxycycline sensitive bacteria in dogs and cats. The major indications include skin infections, infections of thee upper and lower respiratory tract, genitourinary tract infections, middle ear infections, infections of the skeletal system and gastrointestinal tract.
Do not use this product for the last trimester of pregnancy or in neonatal animals (first month of life).
Give 5mg/kg, followed by two doses of 2.5mg/kg at twelve hourly intervals. A maintenance dose of 2.5mg/kg once daily should then be given. Duration of therapy should be typically 5-7 days or for 48 hours after clinical signs have subsided. A longer duration of therapy (up to 28 days) is recommended for chronic urinary, respiratory and skin conditions.
Tablets, 150’s, yellow tablets, quarter scored
Prescription Animal Remedy
Below 25°C (air conditioning).